Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.143.2.215· OSTI ID:6604082

Carr, D H; Brown, J; Bydder, G M; Steiner, R E; Weinmann, H J; Speck, U; Hall, A S; Young, I R

Magnetic resonance imaging (MRI) was performed in 20 patients before and after intravenous administration of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Twelve of the patients had clinical and histologic diagnoses of cerebral tumor, six had hepatic tumors, one had hepatic cysts, and one had transitional cell carcinoma of the bladder. Contrast enhancement was seen with all tumors, but not with the hepatic cysts. The degree of enhancement was greater than that seen with computed tomography (CT) in 13 cases, equal to it in six, and less in one. No short-term side effects were encountered and no significant change was seen in urea, creatinine, electrolytes, liver function tests, blood coagulation, or urine testing after injection of Gd-DTPA. Although much more work will be required to evaluate this contrast agent, these initial experiences are very promising.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 6604082
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 143:2; ISSN AAJRD
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BLADDER
BODY
BRAIN
CARBOXYLIC ACIDS
CARCINOMAS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHELATING AGENTS
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
DRUGS
DTPA
ELEMENTS
GADOLINIUM
GLANDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
LIVER
MAGNETIC RESONANCE
METALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MAGNETIC RESONANCE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIOPROTECTIVE SUBSTANCES
RARE EARTHS
RESONANCE
URINARY TRACT