Gadolinium-phthalein complexone as a contrast agent for hepatobiliary MR imaging

Journal Article · Sat Dec 31 23:00:00 EST 1988 · J. Comput. Assist. Tomogr.; (United States)

DOI:https://doi.org/10.1097/00004728-198901000-00014· OSTI ID:6499835

Kawamura, Y; Endo, K; Koizumi, M; Watanabe, Y; Saga, T; Konishi, J; Horiuchi, K; Yokoyama, A

Gadolinium-phthalein complexone (Gd-PC) was developed as a hepatobiliary magnetic resonance (MR) contrast agent. Phthalein complexone is one of the iminodiacetic acid derivatives and a structural analogue of bromosulfophthalein. Gadolinium-PC substantially enhanced signal intensity of normal functioning livers on T1-weighted MR images. Contrast enhancement of rabbit liver and gradual accumulation of high intensity bile in the gallbladder were observed after intravenous injection of 0.05 and 0.1 mmol/kg Gd-PC. However, 0.1 mmol/kg of Gd-DTPA caused little effect on liver MR.

• Research Organization: Kyoto Univ. (Japan)
• OSTI ID: 6499835
• Journal Information: J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 13:1; ISSN JCATD
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BILE
BILIARY TRACT
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
ELEMENTS
GADOLINIUM
GLANDS
LIVER
MAMMALS
MATERIALS
METALS
NMR IMAGING
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
RABBITS
RARE EARTHS
RATS
RODENTS
VERTEBRATES