Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA

Conference · · Radiology; (United States)
OSTI ID:5650823
; ; ;
Gadolinium-DTPA complex (Gd-DTPA) is a potential clinical magnetic resonance (MR) contrast agent that enhances images primarily by decreasing spin-lattice relaxation time (T1) in tissues in which it localizes. This study was designed to determine the immediate tissue distribution of intravenously administered Gd-DTPA in selected organs of interest as a function of administered dose and tissue GD-DTPA concentrations. An intravenous bolus of Gd-DTPA with a tracer quantity of Gd-153 was administered to three groups of rabbits. The order of tissue relaxation rate response to a given dose was kidney > serum > lung > heart > liver > spleen. The authors conclude that because of its extracellular distribution and linear relaxation rate versus concentration relationship, Gd-DPTA enhancement in MR images may be a good marker of relative organ perfusion.
Research Organization:
Univ. of California Medical Center, San Diego
OSTI ID:
5650823
Report Number(s):
CONF-851152-
Conference Information:
Journal Name: Radiology; (United States) Journal Volume: 154:3
Country of Publication:
United States
Language:
English

Similar Records

Gadolinium-phthalein complexone as a contrast agent for hepatobiliary MR imaging
Journal Article · Sat Dec 31 23:00:00 EST 1988 · J. Comput. Assist. Tomogr.; (United States) · OSTI ID:6499835
Determination of infarct size of acute myocardial infarction in dogs by magnetic resonance imaging and gadolinium-DTPA: Comparison with indium-111 antimyosin imaging
Journal Article · Sat Dec 31 23:00:00 EST 1988 · American Journal of Physiologic Imaging; (USA) · OSTI ID:5226553
Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent
Journal Article · Wed Feb 29 23:00:00 EST 1984 · Am. J. Roentgenol.; (United States) · OSTI ID:6914697

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GADOLINIUM 153
GADOLINIUM CHLORIDES
GADOLINIUM COMPLEXES
GADOLINIUM COMPOUNDS
GADOLINIUM ISOTOPES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEART
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LIVER
LUNGS
MAGNETIC RESONANCE
MAMMALS
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RABBITS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH COMPLEXES
RARE EARTH COMPOUNDS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RELAXATION
RESONANCE
RESPIRATORY SYSTEM
SPIN-LATTICE RELAXATION
SPLEEN
TISSUE DISTRIBUTION
VERTEBRATES