Assessment of exposure to carbon disulfide in viscose production workers from urinary 2-thiothiazolidine-4-carboxylic acid determinations

Journal Article · Tue Dec 31 23:00:00 EST 1991 · American Journal of Industrial Medicine; (United States)

DOI:https://doi.org/10.1002/ajim.4700220108· OSTI ID:6913100

Riihimaeki, V K; Kivistoe, H P; Peltonen, K; Helpioe, E A; Aitio, A ^[1]

---

1. Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki (Finland)

The follow-up of environmental carbon disulfide (CS2) exposure and urinary excretion of 2-thiothiazolidine-4-carboxylic acid (TTCA) among 20 operatives over a 4-day working week in two viscose producing factories confirmed earlier observations that TTCA is a sensitive and reliable indicator of exposure to CS2. Exposure to as low as 0.5-1.0 ppm (1.6-3.2 mg/m3) of CS2 (8-hour time-weighted average [TWA]) was associated with detectable amounts of TTCA in end-of-shift urine. Moreover, the excretion of TTCA, relative to estimated CS2 uptake, appeared surprisingly constant in the studied work force. Approximately 3% (range 2-6.5%) of absorbed CS2 was detected in urine as TTCA. The proportional TTCA excretion did not show dose dependency in the estimated CS2 dose range which varied by about 20-fold. TTCA elimination exhibited both a fast (T 1/2 6 hour) and a slow (T 1/2 68 hour) phase. The slow elimination is compatible with a high lipid solubility and reversible protein binding of CS2. Consequently, urinary excretion of TTCA, relative to CS2 exposure, increased by about a third during the workweek. Urinary TTCA concentration of 4.5 mmol/mol creatinine in a postshift sample corresponded to a TWA exposure to 10 ppm CS2 towards the end of the working week.

• OSTI ID: 6913100
• Journal Information: American Journal of Industrial Medicine; (United States), Journal Name: American Journal of Industrial Medicine; (United States) Vol. 22:1; ISSN AJIMD8; ISSN 0271-3586
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AZOLES
BIOLOGICAL MARKERS
CARBON COMPOUNDS
CARBON SULFIDES
CARBOXYLIC ACIDS
CHALCOGENIDES
CLEARANCE
EXCRETION
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
INDUSTRY
MAMMALS
MAN
METABOLISM
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PERSONNEL
PRIMATES
SULFIDES
SULFUR COMPOUNDS
TEXTILE INDUSTRY
THIAZOLES
VERTEBRATES