Biological monitoring for workers exposed to 4,4'-methylenebis(2-chloroaniline)

Journal Article · Mon Jan 01 04:00:00 EST 1990 · American Industrial Hygiene Association Journal; (USA)

DOI:https://doi.org/10.1202/0002-8894(1990)051<0005:BMFWET>2.0.CO;2· OSTI ID:6936580

Ichikawa, Y; Yoshida, M; Okayama, A; Hara, I; Morimoto, K ^[1]

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1. Kansai Medical Univ., Osaka (Japan)

Absorption of 4,4'-methylenebis (2-chloroaniline) (MBOCA) was assessed for five workers over one week in a polyurethane elastomer factory by measuring urinary MBOCA levels by high performance liquid chromatography (HPLC) using an electrochemical detector. Personal air exposure levels of MBOCA ranged from 0.2 to 8.9 micrograms/m3. The mean urinary MBOCA levels at the beginning and the end of the work shift were 3.1-81.5 and 2.4-96.6 micrograms/g creatinine, respectively. The differences between preshift and postshift urinary MBOCA values were not significant in all workers, according to the paired t-test. The urinary levels after a two-day holiday (on Monday morning) were almost equal to those of preshift levels on other weekdays. Urinary excretion of MBOCA was much higher than the estimated MBOCA levels from personal exposure measurements, suggesting that a significant amount of MBOCA is absorbed by routes other than inhalation. These results lend strong support for the need to monitor exposure control by urinary MBOCA measurement.

• OSTI ID: 6936580
• Journal Information: American Industrial Hygiene Association Journal; (USA), Journal Name: American Industrial Hygiene Association Journal; (USA) Vol. 51:1; ISSN AIHAA; ISSN 0002-8894
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AROMATICS
AZOLES
CHEMICAL INDUSTRY
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
CREATININE
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
INDUSTRY
LIQUID COLUMN CHROMATOGRAPHY
METABOLISM
OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PERSONNEL
POLLUTION
SEPARATION PROCESSES