Metabolism of triethylamine in polyurethane foam manufacturing workers
- University Hospital, Lund (Sweden)
In 20 workers studied before, during, and after exposure to triethylamine (TEA) in a polyurethane-foam producing plant the amount of TEA and its metabolite triethylamine-N-oxide (TEAO) excreted in urine corresponded to an average of 80% of the inhaled amount. An average of 27% was TEAO, but with a pronounced interindividual variation. Older subjects excreted more than younger ones; less than 0.3% was excreted as diethylamine. The data indicate half-lives for TEA and TEAO excretion in urine of about 3 hr. The postshift level of TEA in urine and plasma are good indicators of the time-weighted average air level during the preceding work day, and might thus be used for biological monitoring. An air level of 10 mg/m3 (proposed occupational standard) corresponds to a urinary excretion of 65 mmol TEA/mol creatinine and a plasma level of 1.9 mumol/liter (biological exposure indices).
- OSTI ID:
- 5465759
- Journal Information:
- American Journal of Industrial Medicine; (USA), Journal Name: American Journal of Industrial Medicine; (USA) Vol. 16:3; ISSN 0271-3586; ISSN AJIMD
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AMINES
CHROMATOGRAPHY
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HAZARDS
HEALTH HAZARDS
MATERIALS
METABOLISM
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANIC POLYMERS
PERSONNEL
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
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POLYAMIDES
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POLYURETHANES
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