Fluoride, aluminum, and phosphate kinetics in cryolite workers

Journal Article · Mon Jan 01 04:00:00 EST 1990 · JOM, Journal of Occupational Medicine; (USA)

DOI:https://doi.org/10.1097/00043764-199001000-00015· OSTI ID:6905375

Grandjean, P; Horder, M; Thomassen, Y ^[1]

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1. Odense Univ. (Denmark)

Exposure to cryolite (Na3AlF6) dust may result in skeletal fluorosis. Eight male workers at a cryolite concentrator participated in a 4-day study after 5 days of vacation. Dust exposures were 0.16 to 21.2 mg/m3. Urine was collected before work began and during two 4-hour periods. Preshift urine fluoride concentrations increased during the week. Fluoride concentrations in postshift urine and serum both correlated with the dust exposures. Serum fluoride concentrations decreased with a half-life of 3.3 to 6.9 hours after work. Fluoride clearance was 40.5 to 76.5 mL/min at urinary flow rates of 0.89 to 2.21 mL/min. Serum aluminum concentrations varied without relation to the exposure, but the urinary aluminum excretion correlated with the fluoride levels. Preshift serum-phosphate concentrations increased significantly during the week, possibly indicating changes in mineral metabolism. For monitoring of individual uptake of cryolite dust, serum fluoride measurements are most useful.

• OSTI ID: 6905375
• Journal Information: JOM, Journal of Occupational Medicine; (USA), Journal Name: JOM, Journal of Occupational Medicine; (USA) Vol. 32:1; ISSN 0096-1736; ISSN JJOMD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALUMINIUM
BIOLOGICAL HALF-LIFE
DISEASES
ELEMENTS
FLUORIDES
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
HAZARDS
HEALTH HAZARDS
METABOLISM
METALS
OCCUPATIONAL EXPOSURE
OXYGEN COMPOUNDS
PERSONNEL
PHOSPHATES
PHOSPHORUS COMPOUNDS
POLLUTION
SKELETAL DISEASES