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Effect of synthetic compound B 58 on natural killer and cytostatic cell activity in the mouse spleen

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
DOI:https://doi.org/10.1007/BF00842339· OSTI ID:6905261
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The authors study the effect of compound B 58, a synthetic interferon inducer, on activity of natural killer cells (NKC) and cytostatic effectors in the mouse spleen. NKC activity in the spleen was determined in the 4-hour microtoxicity test against VAC-1 target cells labeled with /sup 51/Cr. /sup 3/H-thymidine was added to the effectors and targets. An increase in activity of the cellular mechanisms of natural antitumor resistance arising under the influence of compound B 58 is shown.
Research Organization:
Institute of Human Morphology, Moscow (USSR)
OSTI ID:
6905261
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 103:6; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOSYNTHESIS
CELL KILLING
CHEMISTRY
CHROMIUM 51
CHROMIUM ISOTOPES
COUNTING TECHNIQUES
CYTOCHEMISTRY
DNA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GROWTH
GROWTH FACTORS
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNE SERUMS
IMMUNOASSAY
IMMUNOLOGY
INHIBITION
INJECTION
INTAKE
INTERFERON
INTERMEDIATE MASS NUCLEI
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LYMPHOKINES
MAMMALS
MICE
MITOGENS
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
RIBOSIDES
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
THYMIDINE
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
UPTAKE
VERTEBRATES