Cytostatic action of cells of the immune system on tumor cells
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The authors study the ability of cells of the immune system to exert a cytostatic action on tumor cells. The target cells used were from mice, and all of the cells were insensitive to the cytotoxic action of the effector cells in the test with /sup 51/Cr. To prevent incorporation of /sup 3/H-uridine by the effector cells they were treated beforehand with actinomycin D. Nonadherent fractions of spleen, bone marrow and thymus cells were used in the experiments. Incorporation of /sup 3/H-thymidine and /sup 3/H-uridine into the cells was determined with a beta-counter. Analysis of the results of this investigation show that the ability of cells of different lymphoid organs to exhibit cytostatic activity is distinct from their ability to exert natural cytotoxic activity.
- Research Organization:
- Research Institute of Human Morphology, Moscow, USSR
- OSTI ID:
- 5785229
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:6; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301* -- Cytology-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BONE MARROW CELLS
CARCINOGENESIS
CELL KILLING
CHEMISTRY
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
CYTOCHEMISTRY
DNA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
INHIBITION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MACROPHAGES
MAMMALS
MICE
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHAGOCYTES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
RNA
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
THYMIDINE
THYMUS CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
URACILS
URIDINE
VERTEBRATES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BONE MARROW CELLS
CARCINOGENESIS
CELL KILLING
CHEMISTRY
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
CYTOCHEMISTRY
DNA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
INHIBITION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MACROPHAGES
MAMMALS
MICE
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHAGOCYTES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
RNA
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
THYMIDINE
THYMUS CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
URACILS
URIDINE
VERTEBRATES