Investigation of the action of some phospholipids and gangliosides on sensitivity of tumor cells to the cytostatic and membrane-toxic action of splenic effectors
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:7166097
This investigation attempts to determine which parts of the lipid molecule are most responsible for the increase in sensitivity of tumor cells to the membrane-toxic and cytostatic action of natural splenic effectors. The characteristics of the lipids used are presented. Splenocytes from BALB/c mice were treated beforehand with actinomycin D to prevent incorporation of tritium-uridine. Either tritium-uridine or tritium-thymidine was added to each well. The experiments showed that ovolecithin, alone, introduced into the membrane of the tumor did not affect its sensitivity to the cytostatic and membrane-toxic action of splenic effectors, whereas a mixture of brain gangliosides actually reduced the sensitivity of target cells.
- Research Organization:
- Institute of Human Morphology, Academy of Medical Sciences of the USSR
- OSTI ID:
- 7166097
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:8; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CARBOHYDRATES
CELL KILLING
CENTRAL NERVOUS SYSTEM
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DRUGS
ESTERS
GANGLIOSIDES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LECITHINS
LEUKOCYTES
LIPIDS
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PYRIMIDINES
RIBOSIDES
RODENTS
SACCHARIDES
SCINTILLATION COUNTING
SENSITIVITY
SOMATIC CELLS
SPLEEN CELLS
THYMIDINE
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
URACILS
URIDINE
VERTEBRATES
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CARBOHYDRATES
CELL KILLING
CENTRAL NERVOUS SYSTEM
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DRUGS
ESTERS
GANGLIOSIDES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LECITHINS
LEUKOCYTES
LIPIDS
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PYRIMIDINES
RIBOSIDES
RODENTS
SACCHARIDES
SCINTILLATION COUNTING
SENSITIVITY
SOMATIC CELLS
SPLEEN CELLS
THYMIDINE
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
URACILS
URIDINE
VERTEBRATES