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Deficient natural killer cell function in preeclampsia

Journal Article · · Obstet. Gynecol.; (United States)
OSTI ID:6186123
Natural killer cell activity of peripheral blood lymphocytes was measured against K-562 target cells with a 4-hour /sup 51/Cr release assay in 15 primigravid women with preeclamptic symptoms. Nineteen primigravid women with an uncomplicated pregnancy and 18 nonpregnant women served as controls. The natural killer cell activity of preeclamptic women was observed to be significantly lower than that of both control groups. Natural killer cells in preeclamptic women responded normally to augmentation caused by interferon. These findings give further evidence for the participation of the maternal immune system in this pregnancy disorder.
Research Organization:
Department of Obstetrics, University of Turku, Finland
OSTI ID:
6186123
Journal Information:
Obstet. Gynecol.; (United States), Journal Name: Obstet. Gynecol.; (United States) Vol. 60:5; ISSN OBGNA
Country of Publication:
United States
Language:
English