Absence of circulating natural killer (NK) cells in a child with erythrophagocytic lymphohistiocytosis lacking NK cell activity
Journal Article
·
· Am. J. Hematol.; (United States)
A 5-year-old girl who was diagnosed as having erythrophagocytic lymphohistiocytosis died at age 9 years. Peripheral lymphocytes from the patient persistently lacked natural killer (NK) cell activity during the 4-year observation period: the percent lysis values as measured by a 4-hr /sup 51/Cr release assay at a 40:1 effector:target ratio were below 1.0% against K562 and Molt-4 cells as compared with the normal lymphocyte value (mean +/- SD) of 46.2% +/- 5.8% and 43.9% +/- 6.7%, respectively. The patient's lymphocytes never developed NK cell activity by their incubation with target cells for longer time periods or by their stimulation with interferon-alpha, interleukin-2, or polyinosinic-polycytidilic acid. Single cell-in-agarose assay showed the absence of target-binding cells (TBCs): TBC numbers were below 0.3% as compared with the normal lymphocyte value of 8.1% +/- 1.3% (mean +/- SD). Flow cytometry showed a marked decrease in Leu-7+ cells (1.7%) and the absence of Leu-11+ cells (0.4%) in the peripheral blood. These results first demonstrate a case of erythrophagocytic lymphohistiocytosis in which there is the lack of NK cell activity due to the absence of circulating NK cells.
- Research Organization:
- Shinshu Univ. School of Medicine, Matsumoto (Japan)
- OSTI ID:
- 7000031
- Journal Information:
- Am. J. Hematol.; (United States), Journal Name: Am. J. Hematol.; (United States) Vol. 28:2; ISSN AJHED
- Country of Publication:
- United States
- Language:
- English
Similar Records
Killing defect of natural killer cells with the absence of natural killer cytotoxic factors in a child with Hodgkin's disease
Immunomodulatory effect of prednisolone (PRD) induced soluble suppressor factor(s) (PRD-SSF) on natural killer (NK) cell activity
Detection of (Leu-7)-positive cells with NK activity in human gingival tissues from patients with periodontitis
Journal Article
·
Mon Jun 01 00:00:00 EDT 1987
· Blood; (United States)
·
OSTI ID:6274990
Immunomodulatory effect of prednisolone (PRD) induced soluble suppressor factor(s) (PRD-SSF) on natural killer (NK) cell activity
Conference
·
Fri Feb 28 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5453498
Detection of (Leu-7)-positive cells with NK activity in human gingival tissues from patients with periodontitis
Conference
·
Tue Mar 04 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:6999945
Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE GROUPS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHILDREN
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
GROWTH FACTORS
HEMIC DISEASES
INTERFERON
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MATERIALS
MITOGENS
NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PHAGOCYTOSIS
PROTEINS
RADIOISOTOPES
SOMATIC CELLS
TRACER TECHNIQUES
VIABILITY
59 BASIC BIOLOGICAL SCIENCES
AGE GROUPS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHILDREN
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
GROWTH FACTORS
HEMIC DISEASES
INTERFERON
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MATERIALS
MITOGENS
NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PHAGOCYTOSIS
PROTEINS
RADIOISOTOPES
SOMATIC CELLS
TRACER TECHNIQUES
VIABILITY