Lung clearance of /sup 99m/Tc-DTPA in patients with acute lung injury and pulmonary edema

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · J. Thorac. Imaging.; (United States)

DOI:https://doi.org/10.1097/00005382-198807000-00008· OSTI ID:6901321

Coates, G; O'Brodovich, H; Dolovich, M

Several acute and chronic conditions that alter the integrity of the pulmonary epithelium increased the rate of absorption or clearance into the circulation of small solutes deposited in the alveoli. Technetium 99m diethylenetriamine pentaacetic acid can be deposited in the lungs as a submicronic aerosol and its rate of clearance measured with a gamma camera or simple probe. This clearance technique is currently being used to evaluate patients who have developed pulmonary edema and also to detect those patients from a high risk group who are likely to develop adult respiratory distress syndrome (ARDS). Its role in the evaluation of patients with pulmonary edema is still under active investigation. It is clear that a single measurement in patients who smoke is not useful, but repeated measurements may provide important information. The lung clearance measurement is very sensitive to changes in epithelial integrity but is not specific for ARDS. It may be most useful in combination with other predictive tests or when the clearance rate is normal. 54 references.

• Research Organization: McMaster Univ., Hamilton, Ontario (Canada)
• OSTI ID: 6901321
• Journal Information: J. Thorac. Imaging.; (United States), Journal Name: J. Thorac. Imaging.; (United States) Vol. 3:3; ISSN JTIME
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DIAGNOSIS
DISEASES
DOCUMENT TYPES
DRUGS
DTPA
EPITHELIUM
EXCRETION
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
PATIENTS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM DISEASES
REVIEWS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES