Measurement of pulmonary epithelial permeability with /sup 99m/Tc-DTPA aerosol

Journal Article · Wed Oct 01 04:00:00 EDT 1986 · Semin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1016/S0001-2998(86)80014-9· OSTI ID:6782035

Coates, G; O'Brodovich, H

The rate at which inhaled aerosol of /sup 99m/Tc-diethylenetriamine pentaacetate (DTPA) leaves the lung by diffusion into the vascular space can be measured with a gamma camera or simple probe. In normal humans, /sup 99m/Tc-DTPA clears from the lung with a half time of about 80 minutes. Many acute and chronic conditions that alter the integrity of the pulmonary epithelium cause an increased clearance rate. Thus cigarette smoking, alveolitis from a variety of causes, adult respiratory distress syndrome (ARDS), and hyaline membrane disease (HMD) in the infant have all been shown to be associated with rapid pulmonary clearance of /sup 99m/Tc-DTPA. Rapid clearance is also promoted by increased lung volume and decreased surfactant activity. Although the mechanism of increased clearance in pathological states is not known, the /sup 99m/Tc-DTPA lung-clearance technique has great potential clinically, particularly in patients at risk from ARDS and HMD and in the diagnosis and follow-up of alveolitis. 58 references.

• Research Organization: McMaster Univ., Hamilton, Ontario
• OSTI ID: 6782035
• Journal Information: Semin. Nucl. Med.; (United States), Journal Name: Semin. Nucl. Med.; (United States) Vol. 4; ISSN SMNMA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DISEASES
DISPERSIONS
DRUGS
DTPA
DYNAMIC FUNCTION STUDIES
EPITHELIUM
EXCRETION
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES