Influence of chest background on pulmonary [sup 99m][Tc]-DTPA clearance in interstitial lung disease

Journal Article · Sat Oct 31 23:00:00 EST 1992 · Journal of Applied Physiology (1985); (United States)

OSTI ID:7060726

Ishizaka, Akitoshi; Kanazawa, Minoru; Suzuki, Yukio; Hasegawa, Naoki; Kubo, Atsushi; Kawashiro, Takeo ^[1]

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1. Keio Univ., Tokyo (Japan)

The authors examined the effect of chest extracellular [sup 99m][Tc]-diethylenetriamine pentaacetate (DTPA) as a background in the measurement of pulmonary [sup 99m][Tc]-DTPA clearance in patients with interstitial lung disease (ILD). Eight healthy nonsmokers (HN) and eight patients with ILD were studied. They monitored changes in gamma counts after the inhalation of [sup 99m][Tc]-DTPA aerosol by using a gamma camera placed over the anterior chest. The rate constant of pulmonary [sup 99m][Tc]-DTPA clearance (k; %/min) was assessed by calculating the slope of the decrease in the gamma counts. The chest background, estimated by [sup 99m][Tc]-DTPA intravenous injection, was subtracted from the original data to obtain the corrected DTPA clearance (k[sub c]; %/min). In patients with ILD, k was significantly greater [2.19 [+-] 1.03 (SD) %/min; n = 8] compared with HN (0.86 [+-] 0.17%/min; n = 8; P < 0.01). In patients with ILD, k[sub c] was also greater (2.80 [+-] 1.15%/min; n = 8; P < 0.01) compared with HN (1.20 [+-] 0.12%/min; n = 8). There was no difference in percent underestimation of k between the two groups (29.1 [+-] 8.8% for HN, 22.5 [+-] 7.9% for patients with ILD). There was a significant correlation between k and k[sub c] among all subjects (r = 0.987, P < 0.01). They conclude that background causes significant underestimation of pulmonary [sup 99m][Tc]-DTPA clearance. 16 refs., 2 figs., 2 tabs.

• OSTI ID: 7060726
• Journal Information: Journal of Applied Physiology (1985); (United States), Journal Name: Journal of Applied Physiology (1985); (United States) Vol. 73:5; ISSN JAPHEV; ISSN 8750-7587
• Country of Publication: United States
• Language: English

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