Reverse lung clearance of Tc-99m DTPA induced by postural changes
Conference
·
· J. Nucl. Med.; (United States)
OSTI ID:5963546
The lung clearance of Tc 99m DTPA is generally attributed to the degree of distension of the interepithelial junctions and thus of the alveoli. To assess this hypothesis a submicronic aerosol of Tc 99m DTPA (0.5 ..mu.. mass median diameter) was inhaled by eight non smoking volunteers placed in left lateral decubitus (LLD) where the alveoli of the left lung are compressed and those of the right lung expanded. The lung radioactivity was followed with a gamma camera 15 minutes in LLD, then 15 minutes in right lateral decubitus (RLD) to reverse the relative distension of the alveoli. Regional clearances were computed on each lung divided in three horizontal slices. These results suggest that alveolar distension has a major role in the DTPA clearance which is relatively independent of the initial deposition of the aerosol.
- Research Organization:
- Hopital Henri Mondor 94000 Creteil
- OSTI ID:
- 5963546
- Report Number(s):
- CONF-850611-
- Conference Information:
- Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
- Country of Publication:
- United States
- Language:
- English
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· J. Nucl. Med.; (United States)
·
OSTI ID:6867727
Related Subjects
550501* -- Metabolism-- Tracer Techniques
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISPERSIONS
DISTRIBUTION
DRUGS
DTPA
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SCINTISCANNING
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
UPTAKE
USES
YEARS LIVING RADIOISOTOPES
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISPERSIONS
DISTRIBUTION
DRUGS
DTPA
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SCINTISCANNING
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
UPTAKE
USES
YEARS LIVING RADIOISOTOPES