Intracellular sodium flux and high-energy phosphorus metabolites in ischemic skeletal muscle

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:6896321

Blum, H; Schnall, M D; Chance, B; Buzby, G P ^[1]

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1. Univ. of Pennsylvania School of Medicine, Philadelphia (USA)

The authors have employed concurrent {sup 31}P- and {sup 23}Na-nuclear magnetic resonance (NMR) spectroscopy in conjunction with the paramagnetic shift reagents dysprosium-chelated tripolyphosphate and triethylenetetramine-hexa-acetic acid to observe the intracellular sodium and phosphorus signals in rat leg muscle. With induced ischemia in the leg, they find slowly falling phosphorylation potential, {Gamma}. At a critical value of {Gamma}, associated with energetic failure of the Na{sup +}-K{sup +} antiport, the intracellular sodium signal begins to increase.

• OSTI ID: 6896321
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ANIMALS
ATP
CARDIOVASCULAR DISEASES
CATIONS
CHARGED PARTICLES
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
ENZYMATIC HYDROLYSIS
HYDROGEN COMPOUNDS
HYDROLYSIS
HYDROXIDES
IONS
ISCHEMIA
ISOTOPES
LIGHT NUCLEI
LYSIS
MAGNETIC RESONANCE
MALES
MAMMALS
MEMBRANE TRANSPORT
MUSCLES
NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHORUS 31
PHOSPHORUS ISOTOPES
RATS
RESONANCE
RODENTS
SODIUM 23
SODIUM COMPOUNDS
SODIUM HYDROXIDES
SODIUM ISOTOPES
SOLVOLYSIS
STABLE ISOTOPES
VASCULAR DISEASES
VERTEBRATES