Some effects of 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene on Friend virus leukemogenesis

Technical Report · Mon May 01 04:00:00 EDT 1978

DOI:https://doi.org/10.2172/6893372· OSTI ID:6893372

Raikow, R B; Okunewick, J P; Meredith, R F; Brozovich, B J; Seeman, P R

The effects of the chemical carcinogens, 7,12-dimethylbenz(a)-anthracene (DMBA) xnd benzo(a)pyrene (PB), on leukemia induction by Friend leukemia virus (FLV) have been evaluated in SJL/J mice. In the viral carcinogen controls, FLV doses of 0.1 SED injected IP caused early leukemia in up to 50% of the recipient animals, which died with characteristic leukemia induced splenomegaly around day 40 after virus injection. The remainder died between 120 and 260 days after FLV, with some splenomegaly but also notably with other symptoms, such as enlarged lymph node and thymus glands. A single dose of 50 ..mu..g DMBA or 500 ..mu..g BP was not found to have any significant tumorigenic effect. However, similar doses of DMBA, given in conjunction with FLV, were found to be unexpectedly protective with regard to the leukemogenic effect of FLV, particularly when given 5 hrs after the virus. On the other hand, pretreatment with BP had an opposite effect, resulting in increased leukemogenesis in SJL/J mice and also in normally virus resistant B10SJF1 mice.

• Research Organization: Allegheny-Singer Research Corp., Pittsburgh, PA (USA)
• OSTI ID: 6893372
• Report Number(s): COO-4800-2
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZANTHRACENE
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGENESIS
CARCINOGENS
CONDENSED AROMATICS
DISEASES
HYDROCARBONS
LEUKEMIA VIRUS
LEUKEMOGENESIS
MAMMALS
MICE
ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
RODENTS
TOXICITY
VERTEBRATES
XYLENES