Potentiation of friend viral leukemogenesis by 9,10-dimethyl-1,2-benzanthracene in two strains of mice (41619)

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-173-41619· OSTI ID:6051671

Raikow, R B; Okunewick, J P; Jones, D L; Buffo, M J

The polycyclic aromatic hydrocarbon, 9,10-dimethyl-1,2-benzanthracene (DMBA) produced malignancy involving the spleen in SJL/J and B10SJF1 mice when injected ip at 500 ..mu..g per mouse either alone or in combination with threshold doses of Friend leukemia virus (FLV). The mice that received both chemical and virus died significantly sooner than mice that received either chemical or virus alone, and a synergism between DMBA and FLV was demonstrated in both the virus-resistant B10SJF1 hybrids and virus-sensitive SJL/F mice. 23 references, 2 figures.

• Research Organization: Allegheny-Singer Research Corp., Pittsburgh, PA
• DOE Contract Number: AC02-78EV04800
• OSTI ID: 6051671
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 173; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
DIMETHYLBENZANTHRACENE
DISEASES
HEMIC DISEASES
INJECTION
INTAKE
LEUKEMIA
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PARASITES
RODENTS
SENSITIVITY
SPLEEN
SYNERGISM
TOXICITY
VERTEBRATES
VIRUSES