Production, purification, and assay of thrombopoietin. Final report, June 1, 1973--June 30, 1978. [X radiation, mice, dogs]
Technical Report
·
OSTI ID:6893227
Studies were conducted on purification and assay of thrombopoietin, the development of neutralizing antibodies to thrombopoietin, and the production of thrombopoietin by kidney cells in culture. The role of platelet-specific antiserum action in thrombocytopenia was investigated. Thrombopoietin was present in sera of thrombocytopenic mice following x radiation or injection of platelet-specific antisera. Studies with dogs showed that platelet cycles are dependent on thrombopoietin and that platelet sizes are altered inversely with platelet counts. The effects of maternal thrombocytopenia on platelet counts of pre- and postnatal mice were investigated as well as the effects of hypoxia on platelet production in mice. (HLW)
- Research Organization:
- Tennessee Univ., Knoxville (USA). Center for the Health Sciences
- OSTI ID:
- 6893227
- Report Number(s):
- ORO-4465-29
- Country of Publication:
- United States
- Language:
- English
Similar Records
Production, purification and assay of thrombopoietin. Progress report, June 1, 1973--Julty 31, 1976. [Mice, /sup 35/S tracer technique, X radiation]
Production, purification and assay of thrombopoietin. Progress report, August 1, 1975--July 31, 1976. [X radiation, /sup 35/S]
Relationships between thrombopoiesis and erythropoiesis: with studies of the effects of preparations of thrombopoietin and erythropoietin. [/sup 59/Fe and /sup 75/Se tracer techniques]
Technical Report
·
Wed Dec 31 23:00:00 EST 1975
·
OSTI ID:7362339
Production, purification and assay of thrombopoietin. Progress report, August 1, 1975--July 31, 1976. [X radiation, /sup 35/S]
Technical Report
·
Wed Dec 31 23:00:00 EST 1975
·
OSTI ID:7195074
Relationships between thrombopoiesis and erythropoiesis: with studies of the effects of preparations of thrombopoietin and erythropoietin. [/sup 59/Fe and /sup 75/Se tracer techniques]
Journal Article
·
Fri Oct 01 00:00:00 EDT 1976
· Blood; (United States)
·
OSTI ID:7349191
Related Subjects
550200 -- Biochemistry
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIBODIES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BLOOD PLATELETS
BODY
BODY FLUIDS
CELL CYCLE
DOGS
ELECTROMAGNETIC RADIATION
FETUSES
HORMONES
IMMUNE SERUMS
IONIZING RADIATIONS
KIDNEYS
MAMMALS
MICE
ORGANS
PURIFICATION
RADIATION EFFECTS
RADIATIONS
RODENTS
SIZE
SYNTHESIS
THROMBOPOIESIS
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIBODIES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BLOOD PLATELETS
BODY
BODY FLUIDS
CELL CYCLE
DOGS
ELECTROMAGNETIC RADIATION
FETUSES
HORMONES
IMMUNE SERUMS
IONIZING RADIATIONS
KIDNEYS
MAMMALS
MICE
ORGANS
PURIFICATION
RADIATION EFFECTS
RADIATIONS
RODENTS
SIZE
SYNTHESIS
THROMBOPOIESIS
VERTEBRATES
X RADIATION