Diethyldithiocarbamate, a superoxide dismutase inhibitor, decreases the radioresistance of Chinese hamster cells
Journal Article
·
· Radiat. Res.; (United States)
A procedure was established by which CuZn superoxide dismutase in Chinese hamster cells was inhibited to 95% by diethyldithiocarbamate. The inhibition was retained after the diethyldithiocarbamate, a potent radioprotector, was washed away. Cells thus treated with diethyldithiocarbamate were more radiosensitive than control cells, the ratio in the presence of oxygen between the D/sub 0/'s of the groups being 1.23. The results are compatible with the proposition that superoxide dismutase contributes to the radioresistance of the cells.
- Research Organization:
- Univ. Hospital of Umea, Sweden
- OSTI ID:
- 6881698
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Diethyldithiocarbamate enhancement of radiation and hyperthermic effects on Chinese hamster cells in vitro. [By inhibition of superoxide dismutase activity thus enhancing superoxide radical toxicity in the cells]
Enhancement of oxygen toxicity by diethyldithiocarbamate on Chinese hamster and mouse cells
Reaction of copper-zinc superoxide dismutase with diethyldithiocarbamate
Journal Article
·
Wed Feb 28 23:00:00 EST 1979
· Radiat. Res.; (United States)
·
OSTI ID:6082836
Enhancement of oxygen toxicity by diethyldithiocarbamate on Chinese hamster and mouse cells
Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5340059
Reaction of copper-zinc superoxide dismutase with diethyldithiocarbamate
Journal Article
·
Sat Nov 24 23:00:00 EST 1979
· J. Biol. Chem.; (United States)
·
OSTI ID:5292794
Related Subjects
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CELL CULTURES
CHELATING AGENTS
COPPER
DATA
DEDTC
DRUGS
ELEMENTS
ENZYME INHIBITORS
ENZYMES
EXPERIMENTAL DATA
HAMSTERS
INFORMATION
MAMMALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDOREDUCTASES
RADICALS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SUPEROXIDE RADICALS
SURVIVAL TIME
TIME DEPENDENCE
TRANSITION ELEMENTS
VERTEBRATES
ZINC
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CELL CULTURES
CHELATING AGENTS
COPPER
DATA
DEDTC
DRUGS
ELEMENTS
ENZYME INHIBITORS
ENZYMES
EXPERIMENTAL DATA
HAMSTERS
INFORMATION
MAMMALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDOREDUCTASES
RADICALS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SUPEROXIDE RADICALS
SURVIVAL TIME
TIME DEPENDENCE
TRANSITION ELEMENTS
VERTEBRATES
ZINC