Fate of inhaled fly ash in hamsters

Journal Article · Fri Aug 01 04:00:00 EDT 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90160-7· OSTI ID:6879868

Wehner, A P; Wilkerson, C L; Mahaffey, J A; Milliman, E M

To determine pulmonary deposition, translocation, and clearance of inhaled fly ash, hamsters received a single 95-min nose-only exposure to neutron-activated fly ash. Over a period of 99 days postexposure, the hamsters were sacrificed in groups of six animals. Lungs, liver, kidneys, decapitated and skinned carcass, pelt, head, gastrointestinal tract, urine, and feces were collected for analysis of the radionuclide tracers /sup 46/Sc, /sup 59/Fe, and /sup 60/Co by ..gamma..-ray spectrometry. The fly ash burden estimates as determined by the radionuclides /sup 46/Sc and /sup 59/Fe are in good agreement for the majority of samples analyzed. An estimated average of 63 ..mu..g fly ash, or 2 to 3% of the inhaled fly ash, was initially retained in the respiratory tract. The estimated biological half-times of the fly ash were 2.6 and 34.5 days, probably for the airways and for the deep lung, respectively. After 99 days, the mean lung burden had decreased to about 10% of its initial value.

• Research Organization: Pacific Northwest Labs., Richland, WA
• OSTI ID: 6879868
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIOLOGICAL PATHWAYS
BODY
BODY BURDEN
CLEARANCE
COBALT 60
COBALT ISOTOPES
DATA
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FLY ASH
HAMSTERS
INFORMATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRON 59
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
TRACER TECHNIQUES
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES