Acute and subchronic inhalation exposures of hamsters to nickel-enriched fly ash

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(79)90061-6· OSTI ID:5566060

Wehner, A P; Moss, O R; Milliman, E M; Dagle, G E; Schirmer, R E

One 6-h inhalation exposure of hamsters to Ni-enriched fly ash (NEFA) aerosol (respirable aerosol concentration approx. 200 ..mu..g/liter) deposited about 80 ..mu..g in the deep lung, of which 75 ..mu..g was still present 30 days postexposure. The animals tolerated the exposure well during the 30-day postexposure observation period. Two-month exposures of hamsters to NEFA or fly ash (FA) aerosols (approx. 185 ..mu..g/liter) resuled in a deep lung burden of about 5.7 mg, dark discoloration of lungs, heavily dust-laden macrophages, and significantly higher lung weights than in controls, but only minimal inflammatory reaction and no deaths. There was no difference between NEFA and FA effects. The NEFA contained 9% Ni; FA contained 0.03% Ni. The results of this study indicate low acute and subchronic toxicity and slow lung clearance of NEFA and FA.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 5566060
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 19:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
COMBUSTION PRODUCTS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENERGY SOURCES
ENVIRONMENTAL EFFECTS
FLY ASH
FOSSIL FUELS
FOSSIL-FUEL POWER PLANTS
FUELS
HAMSTERS
INFLAMMATION
INHALATION
INTAKE
LUNGS
MACROPHAGES
MAMMALS
METALS
NICKEL
ORGANS
PATHOLOGICAL CHANGES
PHAGOCYTES
POWER PLANTS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
THERMAL POWER PLANTS
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES
WASTES