Lund clearance of neutron-activated Mount St. Helens volanic ash in the rat
To determine pulmonary deposition and clearance of inhaled volcanic ash, rats received a single 60-min, nose-only exposure to neutron-activated ash. Over a period of 128 days after exposure, the rats were sacrificed in groups of five animals. Lungs were analyzed for the radionuclide tracers /sup 46/Sc, /sup 59/Fe, and /sup 60/Co by ..gamma..-ray spectrometry. The alveolar ash burdens, detemined by the radionuclides /sup 46/Sc and /sup 59/Fe, are in good agreement for the majority of samples analyzed, indicating ash particulate levels in the lungs, rather than leached radionuclides. The ash deposition estimates based on /sup 60/Co were appreciably lower for the lungs, indicating that /sup 60/Co leached from the ash. Approximately 110 ..mu..g ash, or 6% of the inhaled ash, was initially retained in the deep lung. The biological half-time of the alveolar ash burden was 39 days. After 90 days, the mean lung burden had decreased to about 20% of its initial value; 128 days after exposure, about 10% remained.
- Research Organization:
- Battelle Pacific Northwest Lab., Richland, WA
- OSTI ID:
- 6151747
- Journal Information:
- Environ. Res.; (United States), Vol. 35:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ASHES
ACTIVATION ANALYSIS
LUNGS
GAMMA SPECTROSCOPY
PARTICULATES
LUNG CLEARANCE
RETENTION
BIOLOGICAL HALF-LIFE
CHRONIC EXPOSURE
COBALT 60
EXPERIMENTAL DATA
INHALATION
IRON 59
LEACHING
MT ST HELENS
NEUTRON REACTIONS
RATS
SCANDIUM 46
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VOLCANOES
ANIMALS
BARYON REACTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CASCADE MOUNTAINS
CHEMICAL ANALYSIS
CLEARANCE
COBALT ISOTOPES
DATA
DAYS LIVING RADIOISOTOPES
DISSOLUTION
DISTRIBUTION
EVEN-ODD NUCLEI
EXCRETION
FEDERAL REGION X
HADRON REACTIONS
INFORMATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MOUNTAINS
NORTH AMERICA
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PARTICLES
RADIOISOTOPES
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
SPECTROSCOPY
USA
VERTEBRATES
WASHINGTON
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques