Pulmonary deposition and clearance of a coal fly ash aerosol by inhalation

Journal Article · Wed Oct 01 04:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80181-5· OSTI ID:5117349

Matsuno, K; Tanaka, I; Kodama, Y

Wistar male rats were exposed to coal fly ash aerosols at average exposure concentration of 10.4 mg/m/sup 3/ for 7 hr/day, 5 days/week for 1 month. Some rats were sacrificed just after the exposure, while others were kept for 6 or 10 months clearance time before sacrifice. There were no differences in body weight gains between fly ash exposure groups and controls. The burden of fly ash was estimated by the measurements of aluminum contents in rat organs. Aluminum concentrations in lungs of exposure groups were much higher than those of controls. No apparent deposition of fly ash was observed in the liver, kidneys, spleen, and blood, but lung burdens of up to about 0.7 mg of fly ash were found. The apparent deposition fraction 5.1% after the 1-month exposure. The clearance rate of fly ash deposited in rat lungs may be very slow.

• Research Organization: Univ. of Occupational and Environmental Health, Kitakyushu, Japan
• OSTI ID: 5117349
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 41:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
AEROSOLS
ALUMINIUM
ANIMALS
ASHES
BIOLOGICAL LOCALIZATION
BODY
CARBONACEOUS MATERIALS
CHEMICAL ANALYSIS
CHRONIC EXPOSURE
CLEARANCE
COAL
COLLOIDS
DATA
DEPOSITION
DISPERSIONS
ELEMENTS
ENERGY SOURCES
EXCRETION
EXPERIMENTAL DATA
FLY ASH
FOSSIL FUELS
FUELS
INFORMATION
INHALATION
INTAKE
LUNG CLEARANCE
LUNGS
MAMMALS
MATERIALS
METALS
NUMERICAL DATA
ORGANS
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SOLS
VERTEBRATES
WASTES