In vivo glucose utilization in rat tissues during the three phases of starvation

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Metab., Clin. Exp.; (United States)

DOI:https://doi.org/10.1016/0026-0495(88)90063-7· OSTI ID:6868173

Cherel, Y; Burnol, A F; Leturque, A; Le Maho, Y

Three phases of starvation have been described from changes in protein and lipid utilization in birds and mammals. In the present study, tissue glucose utilization was measured in vivo during these three phases, using a 2-deoxy-(1-3H)glucose technique in the anesthetized rat. According to this technique, the term glucose utilization therefore refers to transport and phosphorylation of glucose in tissues, ie, whatever is the fate of glucose. Whole-body glucose turnover rate, which was determined by a continuous infusion of (3-3H)glucose, decreased by 40% during the first two days of starvation (phase 1); it did not change thereafter, neither in the protein-sparing phase 2 nor in phase 3, which is marked by an increase in net protein breakdown. Two days of starvation caused a marked decrease in the glucose utilization in skeletal muscles; this decrease was higher in oxidative muscles (65% in diaphragm, 66% in soleus) than in glycolytic muscles (31% in extensor digitorum longus, 34% in epitrochlearis). Glucose utilization also decreased in heart atria (75%), heart ventricles (93%), and white adipose tissue (54%); by contrast, there was a two-fold increase in glucose utilization in brown adipose tissue and no change in brain and skin. No variations were observed in glucose utilization in any of the tissues from phase 1 to phase 2. However, phase 3 was marked by a decrease in glucose utilization in extensor digitorum longus (45%), brown adipose tissue (76%), brain (29%), and skin (40%), whereas there was a 2.3- and 3.4-fold increase in glucose utilization in diaphragm and heart ventricles, respectively.

• Research Organization: Laboratoire d'Etude des Regulations Physiologiques, CNRS, Strasbourg (France)
• OSTI ID: 6868173
• Journal Information: Metab., Clin. Exp.; (United States), Journal Name: Metab., Clin. Exp.; (United States) Vol. 37:11; ISSN METAA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
CONNECTIVE TISSUE
FASTING
GLUCOSE
HEART
HEXOSES
IN VIVO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PHOSPHORYLATION
RATS
RODENTS
SACCHARIDES
SKIN
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES