Effect of anesthesia on glucose production and utilization in rats

Journal Article · Sun Mar 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5437223

Penicaud, L; Ferre, P; Kande, J; Leturque, A; Issad, T; Girard, J

This study was undertaken to determine the effects of pentobarbital anesthesia (50 mg/kg ip) on glucose kinetics and individual tissue glucose utilization in vivo, in chronically catheterized rats. Glucose turnover studies were carried out using (3-/sup 3/H) glucose as tracer. A transient hyperglycemia and an increased glucose production were observed 3 min after induction of anesthesia. However, 40 min after induction of anesthesia, glycemia returned to the level observed in awake animals, whereas glucose turnover was decreased by 30% as compared with unanesthetized rats. These results are discussed with regard to the variations observed in plasma insulin, glucagon, and catecholamine levels. Glucose utilization by individual tissues was studied by the 2-(1-/sup 3/H) deoxyglucose technique. A four- to fivefold decrease in glucose utilization was observed in postural muscles (soleus and adductor longus), while in other nonpostural muscles (epitrochlearis, tibialis anterior, extensor digitorum longus, and diaphragm) and other tissues (white and brown adipose tissues) anesthesia did not modify the rate of glucose utilization. A decrease in glucose utilization was also observed in the brain.

• Research Organization: Centre National de la Recherche Scientifique, Meudon-Bellevue, France
• OSTI ID: 5437223
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:3; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ALDEHYDES
ANESTHESIA
ANESTHETICS
ANIMAL TISSUES
ANIMALS
ANTICONVULSANTS
AZINES
BARBITURATES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONNECTIVE TISSUE
DRUGS
GLUCAGON
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
HORMONES
HYPNOTICS AND SEDATIVES
INSULIN
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
MUSCLES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
PHENOBARBITAL
POLYPEPTIDES
PROTEINS
PYRIMIDINES
RATS
RODENTS
SACCHARIDES
TISSUES
TRITIUM COMPOUNDS
VERTEBRATES