Effect of insulin on in vivo glucose utilization in individual tissues of anesthetized lactating rats

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:6283865

Burnol, A F; Ferre, P; Leturque, A; Girard, J

Glucose utilization rate has been measured in skeletal muscles, white adipose tissue, and mammary gland of anesthetized nonlactating and lactating rats. During lactation, basal (1-TH) glucose utilization is decreased by 40% in periovarian white adipose tissue and by 65% in epitrochlearis and extensor digitorum longus but not in soleus muscle. This may be related to the lower blood glucose and plasma insulin concentrations observed during lactation. Basal glucose utilization rate in the mammary gland was, respectively, 18 +/- 2 and 350 +/- 50 g/min in nonlactating and lactating rats. During the euglycemic hyperinsulinemic clamp, a physiological increment in plasma insulin concentration induces a similar increase in glucose utilization rate in skeletal muscles and white adipose tissue in the two groups of rats. Furthermore this low increase in plasma insulin concentration does not alter mammary glucose utilization rate in nonlactating rats but induces the same increase as a maximal insulin concentration in lactating rats. These data show that the active mammary gland is the most insulin-sensitive tissue of the lactating rat that has been tested. The overall increase in insulin sensitivity and responsiveness that has been described in lactating rats can then mainly be attributed to the presence of the active mammary gland. Plasma insulin was determined by radioimmunoassay.

• Research Organization: Centre National de la Recherche Scientifique, Meudon-Bellevue, France
• OSTI ID: 6283865
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:2; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADIPOSE TISSUE
ALDEHYDES
ANESTHESIA
ANIMAL TISSUES
ANIMALS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CONNECTIVE TISSUE
GLANDS
GLUCOSE
HEXOSES
HORMONES
IMMUNOASSAY
IMMUNOLOGY
IN VIVO
INSULIN
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTATION
MAMMALS
MAMMARY GLANDS
MONOSACCHARIDES
MUSCLES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
RODENTS
SACCHARIDES
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES