Combined effect of x irradiation and cell-mediated immune reaction. [Mastocytoma P815-X2 cells from DBA mice and cytotoxic splenic lymphocytes from C57B1 mice were used as target cells and immune cells, respectively]
Journal Article
·
· Radiat. Res.; (United States)
The combined effect of radiation and cell-mediated immune reaction on tumor cells was investigated in vitro. Mastocytoma P815-X2 cells of DBA mice either were irradiated first and subjected to immune lysis by immune splenic lymphocytes of C57Bl mice, or the tumor cells were subjected to immune reaction first and then irradiated. Cell survival was quantitated by colony formation in soft agar medium. It was observed that cellular immune damage to tumor cells did not influence the response of tumor cells to subsequent radiation. Irradiation of tumor cells first, followed by subjection of the cells to cellular immune reaction, slightly enhanced the death of the tumor cells. It appears that this enhanced death might have resulted from a relative increase in the ratio of the number of cytotoxic immune cells to the number of target tumor cells in the incubation mixture as a consequence of the decrease in the number of viable tumor cells by radiation.
- Research Organization:
- Univ. of Minnesota, Minneapolis
- OSTI ID:
- 6858930
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560151 -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISPERSIONS
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RODENTS
SOMATIC CELLS
SUSPENSIONS
THERAPY
TIME DEPENDENCE
TUMOR CELLS
VERTEBRATES
X RADIATION
560151 -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISPERSIONS
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RODENTS
SOMATIC CELLS
SUSPENSIONS
THERAPY
TIME DEPENDENCE
TUMOR CELLS
VERTEBRATES
X RADIATION