Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
- Universite Libre de Bruxelles, Belgium
Suppressor T cells have been shown to be much more radiosensitive than other lymphoid cells, and we have tried to reduce tumor growth by low-dose irradiation. Syngeneic DBA/2 mice received whole-body irradiation (150 rads; 1 rad = 0.01 J/kg) 6 days after P815 tumor inoculation. Tumor growth is significantly reduced in mildly irradiated mice. We also attempted to reduce syngeneic tumor growth by raising immunity against suppressor T cells in two different systems. DBA/2 mice were immunized against splenic T cells collected after disappearance of cytotoxicity and then injected with P815 tumor cells. These mice develop a very high primary cytotoxicity against P815 cells. C57BL/6 mice were immunized against blastic suppressor T cells, before injection of T2 tumor cells. Some of these mice reject the tumor and others develop smaller tumors than control mice. These results could be explained by the induction of antidiotypic activity directed against the immunological receptors of suppressor T lymphocytes, because immunization with blastic suppressor T cells from mice bearing the T2 tumor does not modify the growth of another tumor, T10.
- OSTI ID:
- 6442400
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 78:3; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301 -- Cytology-- Tracer Techniques
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGY
CYTOLOGY
GROWTH
IMMUNITY
IRRADIATION
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RODENTS
THERAPY
TUMOR CELLS
VERTEBRATES
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGY
CYTOLOGY
GROWTH
IMMUNITY
IRRADIATION
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RODENTS
THERAPY
TUMOR CELLS
VERTEBRATES