Dermal toxicity of 8-methoxypsoralen administered (by gavage) to hairless mice irradiated with long-wave ultraviolet light

Journal Article · Tue Nov 01 04:00:00 EST 1977 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12511300· OSTI ID:6858330

Langner, A; Wolska, H; Marzulli, F N; Jablonska, S; Jarzabek-Chorzelska, M; Glinski, W; Pawinska, M

Hairless mice were administered various amounts of 8-methoxypsoralen (8-MOP) by gavage, followed by irradiation with ultraviolet light (UVA) two or more times per week for periods ranging from 1 to 12 months. The minimum phototoxic dose was 20 mg/kg body weight by this route of administration and potential for serious organ toxicity in long-term exposures was investigated. No histologic features of cutaneous malignancy were encountered under test conditions which produced prolonged phototoxicity, deep ulceration, cicatrization, and other deformities. Repeated daily gavaged doses of 20 mg psoralen/Kg body weight in conjunction with twice weekly irradiation for 10 min with UVA elicited an erythematous phototoxic reaction, but did not give rise to subsequent skin lesions. 8-MOP in repeated daily gavage doses of 30 mg and 40 mg/kg body weight combined with twice weekly UVA irradiation for 10 min caused severe burning with subsequent scarring, but did not induce malignant tumors in experiments lasting 8 months. No organ toxicity was seen except for toxic liver changes when severe cutaneous burn and pronounced ulcerations were produced. Limited immunologic studies disclosed no abnormalities in this system.

• Research Organization: Warsaw Medical School
• OSTI ID: 6858330
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 69:5; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKOXY RADICALS
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BODY
CHRONIC EXPOSURE
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
HETEROCYCLIC COMPOUNDS
INJURIES
LIVER
MAMMALS
METHOXY RADICALS
MICE
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PSORALEN
RADIATIONS
RADICALS
RODENTS
SIDE EFFECTS
SKIN
TOXICITY
ULTRAVIOLET RADIATION
VERTEBRATES