Phototoxic effects of 8-methoxypsoralen on rabbit corneal endothelium

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Lens and Eye Toxicity Research; (USA)

OSTI ID:6057023

Menon, I A; Basu, P K; Hasany, S M; Persad, S D ^[1]

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1. Univ. of Toronto, Ontario (Canada)

The phototoxic effects of 8-methoxypsoralen (8-MOP) were investigated using the rabbit corneal endothelium in organ culture. The corneas were divided into four groups: (a) irradiated with a mercury vapor lamp (emitting UVA and visible radiation) in the presence of 8-MOP (experimental), (b) irradiated without 8-MOP (control A), (c) incubated with 8-MOP (control B) and (d) incubated without 8-MOP (control C). Specular and light microscopic examination showed that the experimental corneas had greater cellular damage compared to the control corneas. The effects of 8-MOP were restricted to certain localized areas of the cornea. However there was no significant difference in the amounts of 51Cr released from the labelled experimental and control corneas. These results show phototoxic damage of the corneal endothelial cells.

• OSTI ID: 6057023
• Journal Information: Lens and Eye Toxicity Research; (USA), Vol. 6:1-2; ISSN 1042-6922
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
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RADIOSENSITIZERS
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DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORGANS
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RADIATIONS
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560120* - Radiation Effects on Biochemicals
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550901 - Pathology- Tracer Techniques