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Phototoxic effects of 8-methoxypsoralen on rabbit corneal endothelium

Journal Article · · Lens and Eye Toxicity Research; (USA)
OSTI ID:6057023
; ; ;  [1]
  1. Univ. of Toronto, Ontario (Canada)
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The phototoxic effects of 8-methoxypsoralen (8-MOP) were investigated using the rabbit corneal endothelium in organ culture. The corneas were divided into four groups: (a) irradiated with a mercury vapor lamp (emitting UVA and visible radiation) in the presence of 8-MOP (experimental), (b) irradiated without 8-MOP (control A), (c) incubated with 8-MOP (control B) and (d) incubated without 8-MOP (control C). Specular and light microscopic examination showed that the experimental corneas had greater cellular damage compared to the control corneas. The effects of 8-MOP were restricted to certain localized areas of the cornea. However there was no significant difference in the amounts of 51Cr released from the labelled experimental and control corneas. These results show phototoxic damage of the corneal endothelial cells.

OSTI ID:
6057023
Journal Information:
Lens and Eye Toxicity Research; (USA), Journal Name: Lens and Eye Toxicity Research; (USA) Vol. 6:1-2; ISSN 1042-6922; ISSN LETRE
Country of Publication:
United States
Language:
English

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Related Subjects

550901 -- Pathology-- Tracer Techniques
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHROMIUM 51
CHROMIUM ISOTOPES
CORNEA
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ENDOTHELIUM
EVALUATION
EVEN-ODD NUCLEI
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORGANS
RABBITS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
SENSE ORGANS
TISSUE CULTURES
TISSUES
TRACER TECHNIQUES
ULTRAVIOLET RADIATION
VERTEBRATES