Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice
The tissue distribution and excretion of (/sup 3/H)8-methoxypsoralen (8-MOP), a well-accepted therapeutic agent for the treatment of psoriasis, was studied in hairless HRA/Skh female mice. Mice were given single oral doses of 6 mg of (/sup 3/H)8-MOP or 5-(/sup 14/C)8-MOP/kg in corn oil. Radiochemical analyses of tissues and excreta were accomplished by liquid scintillation counting. The 8-MOP appeared to be rapidly absorbed through the gastrointestinal tract, where the tritium levels were highest, followed by skin, blood, and liver; levels were lowest in fat (adipose tissue). In female HRA/Skh mice which had not been irradiated with UVA (320-400 nm), 84% of the carbon-14 and 58% of the tritium were recovered in the urine and feces within 24 hours of oral administration of 5-(/sup 14/C)8-MOP or (/sup 3/H)8-MOP, respectively. Animals that were exposed to UVA and received (3H)8-MOP excreted approximately 12% less tritium in the urine and feces compared with the animals which received no UVA.
- Research Organization:
- Bioassay Systems Corp., Woburn, MA
- OSTI ID:
- 5414391
- Journal Information:
- Natl. Cancer Inst. Monogr.; (United States), Vol. 66
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
NEAR ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
PSORALEN
RETENTION
TISSUE DISTRIBUTION
ADIPOSE TISSUE
BIOASSAY
BLOOD
CARBON 14 COMPOUNDS
FECES
GASTROINTESTINAL TRACT
LIQUID SCINTILLATORS
LIVER
MICE
SCINTILLATION COUNTING
SKIN
TRITIUM COMPOUNDS
URINE
ANIMAL TISSUES
ANIMALS
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CONNECTIVE TISSUE
COUMARINS
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHOSPHORS
RADIATIONS
RODENTS
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques