Excretion and tissue disposition of dichloroacetonitrile in rats and mice
The excretion and tissue distribution of (1-/sup 14/C)dichloroacetonitrile and (2-/sup 14/C)dichloroacetonitrile were studied in male Fischer 344 rats and male B6C3F1 mice. Three dose levels of dichloroacetonitrile (DCAN) (0.2, 2, or 15 mg/kg) were administered to rats and two dose levels of DCAN (2 or 15 mg/kg) to mice. Daily excreta including exhaled volatiles and radiolabeled carbon dioxide (/sup 14/CO/sub 2/) were analyzed for radiolabeled carbon (/sup 14/C) until greater than 70% of the radioactivity was excreted. At that time the animals were sacrificed and tissues were collected. Tissues and excreta were analyzed for /sup 14/C by combustion and liquid scintillation counting. Rats administered (1-/sup 14/C)DCAN excreted 62 to 73% of the /sup 14/C in 6 days, with 42 to 45% in urine, 14 to 20% in feces, and 3 to 8% as CO/sub 2/. Rats administered (2-/sup 14/C)DCAN excreted 82 to 86% of the /sup 14/C in 48 hr, with 35 to 40% in urine, 33 to 34% as CO/sub 2/, and 10 to 13% in feces. Mice administered (1-/sup 14/C)DCAN excreted 83 to 85% of the /sup 14/C in 24 hr, with 64 to 70% in urine, 9 to 13% in feces, and 5 to 6% as CO/sub 2/. Mice administered (2-/sup 14/C)DCAN excreted 84 to 88% of the /sup 14/C in 24 hr with 42 to 43% in urine, 8 to 11% in feces, and 31 to 37% as CO/sub 2/. Liver tissues retained the most /sup 14/C in all studies except the study of (1-/sup 14/C)DCAN in rats, where blood contained the most /sup 14/C. These results indicate that DCAN was absorbed rapidly after oral administration in water. The differences in the route of excretion of (1-/sup 14/C)DCAN compared to (2-/sup 14/C)DCAN indicated that the molecule was being cleaved in the body and metabolized by different mechanisms.
- Research Organization:
- Univ. of Arizona, Tucson
- OSTI ID:
- 6583337
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States); ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETONITRILE
ANIMALS
BIODEGRADATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CHEMICAL REACTIONS
CLEARANCE
COUNTING TECHNIQUES
DECOMPOSITION
DISINFECTANTS
DISTRIBUTION
EXCRETION
GERMICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
MICE
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
RATS
RODENTS
SCINTILLATION COUNTING
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES
WATER SUPPLY