Metabolism of {sup 14}C triadimefon in rats
- Bayer, Stilwell, KS (United States)
[Phenyl-UL-{sup 14}C] triadimefon was administered orally to male and female Wistar rats at a rate of 5 or 50 mg/kg body weight. After dosing, the triadimefon was rapidly absorbed, metabolized, and excreted in urine and feces. In the male rats, 27-28% of the administered radioactivity was excreted in the urine, and 63% was excreted in the feces, within 96 hours after dosing. In the female rats, 61-66% of the administered radioactivity was excreted in urine, and 32-37% was excreted in the feces, within 96 hours after dosing. Less than <1% of the administered radioactivity was expired as volatile organic products, including {sup 14}CO{sub 2}, during the study period. Several major (>10%) as well as minor (<10%) metabolites were excreted in the urine and feces. The major metabolites were identified as KWG 1323, KWG 1342, KWG 0519 acid, and their glucuronides; the other major metabolites were KWG 0519 dehydrate, desmethyl KWG 1342 glucuronide, and hydroxy desmethyl KWG 1342. The minor metabolites were identified as desmethyl KWG 1342, desmethyl KWG 1342-cyclic sulfate, hydroxy desmethyl KWG 1342, KWG 0519 dehydrate, chlorophenoxytriazolylacetic acid, p-chlorophenol, and p-chlorophenol sulfate. Unmetabolized parent triadimefon was detected only in the feces and only in trace amounts (<1%).
- OSTI ID:
- 369961
- Report Number(s):
- CONF-960376--
- Country of Publication:
- United States
- Language:
- English
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