Metabolism of {sup 14}C triadimefon in rats

Conference · Tue Oct 01 04:00:00 EDT 1996

OSTI ID:369961

Chopade, H M; Fitzpatrick, T L; Murphy, J J ^[1]

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1. Bayer, Stilwell, KS (United States)

[Phenyl-UL-{sup 14}C] triadimefon was administered orally to male and female Wistar rats at a rate of 5 or 50 mg/kg body weight. After dosing, the triadimefon was rapidly absorbed, metabolized, and excreted in urine and feces. In the male rats, 27-28% of the administered radioactivity was excreted in the urine, and 63% was excreted in the feces, within 96 hours after dosing. In the female rats, 61-66% of the administered radioactivity was excreted in urine, and 32-37% was excreted in the feces, within 96 hours after dosing. Less than <1% of the administered radioactivity was expired as volatile organic products, including {sup 14}CO{sub 2}, during the study period. Several major (>10%) as well as minor (<10%) metabolites were excreted in the urine and feces. The major metabolites were identified as KWG 1323, KWG 1342, KWG 0519 acid, and their glucuronides; the other major metabolites were KWG 0519 dehydrate, desmethyl KWG 1342 glucuronide, and hydroxy desmethyl KWG 1342. The minor metabolites were identified as desmethyl KWG 1342, desmethyl KWG 1342-cyclic sulfate, hydroxy desmethyl KWG 1342, KWG 0519 dehydrate, chlorophenoxytriazolylacetic acid, p-chlorophenol, and p-chlorophenol sulfate. Unmetabolized parent triadimefon was detected only in the feces and only in trace amounts (<1%).

• OSTI ID: 369961
• Report Number(s): CONF-960376--
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CARBON 14
FECES
LABELLED COMPOUNDS
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
RATS
TRACE AMOUNTS
TRACER TECHNIQUES
URINE