Metabolism and disposition of dipropylene glycol monomethyl ether (DPGME) in male rats

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(85)90196-4· OSTI ID:6430336

Miller, R R; Hermann, E A; Calhoun, L L; Kastl, P E; Zakett, D

Male Fischer 344 rats were given a single oral dose of approximately 1289 mg/kg (8.7 mmol/kg) of (/sup 14/C)DPGME. After dosing, expired air, excreta, and tissues were analyzed for /sup 14/C activity, and metabolites in urine were isolated and identified. Approximately 60% of the administered /sup 14/C activity was excreted in urine, while 27% was eliminated as /sup 14/CO/sub 2/ within 48 hr after dosing. DPGME, PGME, dipropylene glycol, propylene glycol, as well as sulfate and glucuronide conjugates of DPGME were identified in urine of animals given (/sup 14/C)DPGME. Results of the study indicate that DPGME is metabolized via the same routes to the same general types of metabolites as previously identified for propylene glycol monomethyl ether (PGME).

• Research Organization: Mammalian and Environmental Toxicology Research Lab., Midland, MI
• OSTI ID: 6430336
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 4; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CHEMICAL REACTIONS
CLEARANCE
DEALKYLATION
DISTRIBUTION
ETHERS
EXCRETION
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RATS
RODENTS
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES