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Metabolism and disposition of propylene glycol monomethyl ether (PGME) beta isomer in male rats

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
; ; ;

Male Fischer 344 rats were given a single po dose of approximately 1 or 8.7 mmol/kg of radiolabelled propylene glycol monomethyl ether (PGME) beta isomer (2-methoxy-1-propanol). After dosing, expired air, excreta, and tissues were analyzed for 14C activity and metabolites in urine were isolated and identified. Approximately 70 to 80% of the 14C was excreted in urine while about 10 to 20% was eliminated as 14CO2 within 48 hr after dosing. The major urinary metabolite was 2-methoxypropionic acid, which accounted for approximately 93 and 79% of the radioactivity in urine from high- and low-dose animals, respectively. A glucuronide conjugate of the PGME beta isomer was also identified in urine; this metabolite accounted for approximately 3 to 4% of the radioactivity in the urine at both dosages. These results indicate that the PGME beta isomer is metabolized via different routes to different types of metabolites in comparison to the PGME alpha isomer. While the two isomers are biotransformed differently, there is a substantial toxicological data base which clearly shows that the commercial grade PGME mixture (2 to 5% beta isomer) has a low degree of biological activity.

Research Organization:
Mammalian and Environmental Toxicology Research Laboratory, Midland, MI
OSTI ID:
5614716
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 1; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CLEARANCE
DISTRIBUTION
ETHERS
EXCRETION
FECES
GLYCOLS
HYDROXY COMPOUNDS
ISOMERS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
MATERIALS
METABOLISM
METABOLITES
NUCLEAR MAGNETIC RESONANCE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RATS
RESONANCE
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES