Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats

Journal Article · Tue Oct 01 04:00:00 EDT 1985 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(85)90182-4· OSTI ID:5631820

Dutcher, J S; Medinsky, M A; Bond, J A; Cheng, Y S; Snipes, M B; Henderson, R F; Birnbaum, L S

2,3-Dichloropropene (DCP) is an intermediate used in the manufacture of carbamate herbicides and there is potential for human exposure during the manufacturing process. DCP is a known mutagen in bacteria systems and some structural analogs of DCP are carcinogenic. Since little is known about the disposition of DCP in animals after inhalation, studies were conducted in male Fischer-344 rats to determine the effect of vapor concentration on absorption and excretion. Uptake and elimination of /sup 14/C was studied in rats after nose-only inhalation of 17, 240, or 1650 nmol of (/sup 14/C)DCP vapor/liter of air (0.4, 6, or 40 ppm, respectively, at 760 mm and 25 degrees C) for 6 hr. The percentage of inhaled DCP absorbed averaged 38% and was not statistically different at any vapor concentration, although minute volume was lower during exposure to 1650 nmol/liter. Urine, feces, and expired air were collected from rats for 65 hr after exposure. Rats were sacrificed and tissues, carcass, excreta, and expired air were analyzed for /sup 14/C. Routes of /sup 14/C excretion were independent of vapor concentration, with 50% of the /sup 14/C excreted in urine, 13% in feces, approximately 7% as CO/sub 2/, and less than 1% as DCP in expired air. Rates of /sup 14/C excretion were also independent of vapor concentration, with the half-times averaging 9.9 hr (urine), 13.6 hr (feces), and 0.9 hr (/sup 14/CO/sub 2/). Sixty hours after inhalation, 29% of the initial body burden of /sup 14/C remained in the carcass. Most was associated with the pelt, but some /sup 14/C was found in all tissues. Respiratory tract, GI tract, liver, and kidney were tissues with the highest /sup 14/C contents. The results indicate that DCP metabolism and excretion rates are relatively constant throughout the vapor concentration range studied.

• OSTI ID: 5631820
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 5; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY BURDEN
BODY FLUIDS
CARBON 14 COMPOUNDS
CHLORINATED ALIPHATIC HYDROCARBONS
CLEARANCE
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
FECES
FLUIDS
GASES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HERBICIDES
INHALATION
INTAKE
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VAPORS
VERTEBRATES
WASTES