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Disposition of ( UC)methyl bromide in rats after inhalation

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
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The purpose of this investigation was to determine the disposition and metabolism of ( UC)methyl bromide in rats after inhalation. Male Fischer-344 rats were exposed nose only to a vapor concentration of 337 nmol ( UC)methyl bromide/liter air (9.0 ppm, 25C, 620 torr) for 6 hr. Urine, feces, expired air, and tissues were collected for up to 65 hr after exposure. Elimination of UC as UCO2 was the major route of excretion with about 47% (3900 nmol/rat) of the total ( UC)methyl bromide absorbed excreted by this route. CO2 excretion exhibited a biphasic elimination pattern with 85% of the UCO2 being excreted with a half-time of 3.9 +/- 0.1 hr (anti x +/- SE) and 15% excreted with a half-time of 11.4 +/- 0.2 hr. Half-times for elimination of UC in urine and feces were 9.6 +/- 0.1 and 16.1 +/- 0.1 hr, respectively. By 65 hr after exposure, about 75% of the initial radioactivity had been excreted with 25% remaining in the body. Radioactivity was widely distributed in tissues immediately following exposure with lung (250 nmol equivalents/g), adrenal (240 nmol equivalents/g), and nasal turbinates (110 nmol equivalents/g) containing the highest concentrations of UC. Radioactivity in livers immediately after exposure accounted for about 17% of the absorbed methyl bromide. Radioactivity in all other tissues examined accounted for about 10% of the absorbed methyl bromide. Elimination half-times of UC from tissues were on the order of 1.5 to 8 hr. In all tissues examined, over 90% of the UC in the tissues was methyl bromide metabolities. The data from this study indicate that after inhalation methyl bromide is rapidly metabolized in tissues and readily excreted. 22 references, 4 figures, 4 tables.

Research Organization:
Inhalation Toxicology Research Institute, Albuquerque, NM
DOE Contract Number:
AC04-76EV01013
OSTI ID:
6234784
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 78; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
ANIMALS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
BROMINATED ALIPHATIC HYDROCARBONS
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CLEARANCE
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
EXCRETION
EXPERIMENTAL DATA
FECES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
INFORMATION
INHALATION
INTAKE
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
METHYL BROMIDE
NUMERICAL DATA
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES