Deposition of inhaled particulate matter in the upper respiratory tract, larynx, and bronchial airways: a mathematical description. [Man]
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
A mathematical description of inhaled particle behavior suitable for analysis of factors affecting deposition in the human upper respiratory tract (nasopharyngeal and oropharyngeal compartments), larynx, and ciliated airways is presented. When upper respiratory tract and larynx filtering efficiencies are incorporated in the model, theoretical calculations of aerosol deposition agree with tracheobronchial (TB) data reported in the open literature. The model predicts the sigmoidal shape of TB deposition patterns measured in human subjects, the slopes of the quasilinear segments of these curves, and the positions of their two asymptotes. The model could therefore be used to evaluate the health effects of toxic airborn particles.
- Research Organization:
- Univ. of North Carolina School of Medicine, Chapel Hill
- OSTI ID:
- 6846601
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 12:4-6; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BRONCHI
DEPOSITION
FORECASTING
INHALATION
INTAKE
MAMMALS
MAN
MATHEMATICAL MODELS
PARTICLES
PARTICULATES
PRIMATES
RESPIRATORY SYSTEM
TRACHEA
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BRONCHI
DEPOSITION
FORECASTING
INHALATION
INTAKE
MAMMALS
MAN
MATHEMATICAL MODELS
PARTICLES
PARTICULATES
PRIMATES
RESPIRATORY SYSTEM
TRACHEA
VERTEBRATES