Mathematical modeling of deposition of inhaled particles in the human respiratory tract

Thesis/Dissertation · Fri Jan 01 04:00:00 EST 1982

OSTI ID:6586017

Diu, C K

Inhaled particle deposition in human respiratory tract have been studied systematically by using a mathematical model. Empirical equations have been developed for extrathoracic deposition and the inertial deposition equation in the tracheobronchial tree was derived. The basic parameters governing deposition were first discussed and the lung deposition model was tested under different breathing conditions. Various calculations were made by using different lung models and for different particle characteristics, such as polydisperse aerosol and charged particles. Comparison with available controlled experimental data was made and discussed. Intersubject variability of this data was found to be caused principally by dimensional differences of airways, using a statistical two-compartmental lung model. A more detailed generation-by-generation compartmental lung model was also developed under certain assumptions. Finally, depositions for various combined-breathing states were also evaluated.

• OSTI ID: 6586017
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
BODY
BRONCHI
COLLOIDS
DEPOSITION
DISPERSIONS
INHALATION
INTAKE
LUNGS
MATHEMATICAL MODELS
ORGANS
PARTICLES
PARTICULATES
RESPIRATORY SYSTEM
SOLS