The respiratory tract deposition model proposed by the ICRP Task Group

Conference · Wed Oct 31 23:00:00 EST 1990

OSTI ID:6226124

James, A C; Briant, J K ^[1]; Stahlhofen, W; Rudolf, G ^[2]; Egan, M J; Nixon, W ^[3]; Gehr, P ^[4]

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1. Pacific Northwest Lab., Richland, WA (USA)
2. Gesellschaft fuer Strahlen- und Umweltforschung mbH Muenchen, Frankfurt am Main (Germany, F.R.). Abt. fuer Biophysikalische Strahlenforschung
3. AEA Safety and Reliability, Culcheth (UK)
4. Bern Univ. (Switzerland). Anatomisches Inst.

The Task Group has developed a new model of the deposition of inhaled aerosols in each anatomical region of the respiratory tract. The model is used to evaluate the fraction of airborne activity that is deposited in respiratory regions having distinct retention characteristics and clearance pathways: the anterior nares, the extrathoracic airways of the naso- and oropharynx and larynx, the bronchi, the bronchioles, and the alveolated airways of the lung. Drawn from experimental data on total and regional deposition in human subjects, the model is based on extrapolation of these data by means of a detailed theoretical model of aerosol transport and deposition within the lung. The Task Group model applies to all practical conditions, and for aerosol particles and vapors from atomic size up to very coarse aerosols with an activity median aerodynamic diameter of 100 {mu}m. The model is designed to predict regional deposition in different subjects, including adults of either sex, children of various ages, and infants, and also to account for anatomical differences among Caucasian and non-Caucasian subjects. The Task Group model represents aerosol inhalability and regional deposition in different subjects by algebraic expressions of aerosol size, breathing rates, standard lung volumes, and scaling factors for airway dimensions. 35 refs., 13 figs., 2 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• Sponsoring Organization: DOE/EH
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6226124
• Report Number(s): PNL-SA-18335; CONF-900733--7; ON: DE91007209
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AGE DEPENDENCE
CLEARANCE
COLLOIDS
DATA
DISPERSIONS
DISTRIBUTION
DOSIMETRY
FLUIDS
GASES
INFORMATION
INHALATION
INTAKE
MATHEMATICAL MODELS
NUMERICAL DATA
RADIATION PROTECTION
RADIOACTIVE AEROSOLS
RESPIRATORY SYSTEM
RETENTION
SEX DEPENDENCE
SOLS
THEORETICAL DATA
TISSUE DISTRIBUTION
VAPORS