Absorption of diethylenetriaminepentaacetic acid (DTPA) from the respiratory tracts of beagle dogs

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668091424285· OSTI ID:5128673

Dudley, R E; Muggenburg, B A; Cuddihy, R G; McClellan, R O

Absorption of diethylenetriaminepentaacetic acid (DTPA) from the nasopharyngeal (NP), tracheobronchial (TB) and pulmonary (P) regions of beagle dogs was determined because of the current interest in aerosolized DTPA as a method for the removal of radionuclides deposited in the respiratory tract. Radiolabeled DTPA was instilled into the NP, TB and P regions of dogs and its subsequent translocation was followed for 48 hours. Results revealed that l6, 48 and 90% of the instilled DTPA was absorbed into the circulatory system from the NP, TB and P regions, respectively. A comparison was also made between NP absorption of aerosolized as opposed to instilled DTPA. Nasopharyngeal absorption (23%) of aerosolized DTPA was slightly higher than that of instilled DTPA. Further, DTPA deposited in the respiratory tract remained in the body longer than intravenously injected DTPA. These findings indicate that a substantial quantity of DTPA is absorbed from all regions of the respiratory tract and that DTPA need not be deposited within the deep lung to produce systemic absorption of DTPA for the removal of internally deposited radioactive isotopes.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• DOE Contract Number: EY-76-C-04-1013
• OSTI ID: 5128673
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 41:1; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINO ACIDS
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CLEARANCE
COLLOIDS
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
HEART
INDIUM 111
INDIUM ISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LUNG CLEARANCE
LUNGS
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SOLS
TABLES
TRANSLOCATION
VERTEBRATES