Lung clearance of inhaled /sup 99m/Tc-DTPA in the dog

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States)

OSTI ID:5446268

Oberdoerster, G; Utell, M J; Weber, D A; Ivanovich, M; Hyde, R W; Morrow, P E

A study was made of the reproducibility of measuring an index of permeability of respiratory epithelium in dogs using aerosolized /sup 99m/Tc-DTPA (diethylenetriaminepentaacetate). The method uses a gamma camera to measure the rate of clearance of soluble radioactive aerosol deposited in the lung. A solution of /sup 99m/Tc-DTPA in normal saline was aerosolized by an ultrasonic nebulizer. Eleven anesthetized dogs breathing spontaneously inhaled the resulting droplets for 2 min. Mass median aerodynamic diameter of the droplets was 4.4 ..mu..m with a geometric standard deviation of 2.1. Clearance from the lung was monitored by quantitative gamma camera imaging for up to 2 h. For a 60-min observation period, the biological half-life for clearance of /sup 99m/Tc-DTPA from both lungs was 66 +/- 11 (SD) min. Apical regions cleared significantly slower than basal regions, probably because of a larger portion of bronchial tissue in the apical region of the dog's lung. The best reproducibility of absorption of /sup 99m/Tc-DTPA in the dog was obtained from basal regions and peripheral zones of the lung within 30 min after inhalation of the radioaerosol.

• Research Organization: Univ. of Rochester School of Medicine and Dentistry, NY
• DOE Contract Number: AC02-76EV03490
• OSTI ID: 5446268
• Journal Information: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Journal Name: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States) Vol. 57:2; ISSN JARPD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COMPARATIVE EVALUATIONS
DATA
DISPERSIONS
DOGS
DRUGS
DTPA
EPITHELIUM
EXCRETION
EXPERIMENTAL DATA
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
IMAGES
INFORMATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MATERIALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RETENTION
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES