Deposition of fluorescent polystyrene microspheres in simulated human casts of the oral cavity to the upper bronchial region

Technical Report · Tue Nov 01 04:00:00 EST 1994

OSTI ID:54794

Chen, B T; Cheng, Kuo-Hsi; Swift, D L ^[1]; Schum, S P; Yeh, Hsu-Chi

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1. John Hopkins Univ., Baltimore, MD (United States)

Asthmatic patients often use inhalers to deliver medication to their lungs, and many current inhalers contain chlorofluorocarbons (CFCs) as propellant. Due to the damage that CFCs pose to the earth`s ozone layer, these inhalers will soon be replaced by alternative methods. One possibility is that drugs in the form of dry powder could be administered by oral inhalation. Numerous studies have been performed on the deposition of aerosol particles in upper respiratory tract casts of humans. These studies and several others have been summarized by Yu, C.P. et al. Although mathematical models exist for the tracheobronchial (TB) and pulmonary regions of the lungs, the complex anatomy of the oral, oropharyngeal and laryngeal (OPL) region makes it difficult to model the depositions in the complete respiratory tract. The present study provides experimental data on the fractional deposition of monodisperse aerosol particles (ranging from 3 to 22 {mu}m) in the OPL and TB regions using silicone rubber ({open_quotes}silastic{close_quotes}) casts at a constant 30 L/min flow rate through the mouth. The purpose was to determine the deposition {open_quotes}hot spots{close_quotes} of micrometer size dry powders in different regions of the respiratory tract after a moderate oral puff.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• DOE Contract Number: FG02-88ER60655; AC04-76EV01013
• OSTI ID: 54794
• Report Number(s): ITRI--144; ON: DE95007526
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANATOMY
ASTHMA
BIOLOGICAL HOT SPOTS
CHLOROFLUOROCARBONS
DRUGS
INHALATION
MICROSPHERES
POWDERS
PROGRESS REPORT
RESPIRATORY SYSTEM
RETENTION