Fate of inhaled particles in the human. Comparison of experimental data with theoretical computations based on a symmetric and asymmetric lung
Journal Article
·
· Bull. Math. Biol.; (United States)
An analytical model is used to describe the behavior of inhaled particulate matter in the human respiratory tract. Three different geometries, symmetric and asymmetric, are utilized to simulate the tracheobronchial (TB) tree. The suitability of each geometry for representing the human is evaluated by comparing calculated aerosol deposition probabilities with experimental data from inhalation exposure tests. A symmetric, dichotomously branching pattern is found to be a reliable description of the TB tree for studies of factors affecting aerosol deposition in the human lung. Calculations with the theoretical model are in excellent agreement with measured aerosol deposition efficiencies. Furthermore, the model accurately predicts experimentally observed features of inhalation exposure data, such as effects of inter-subject lung morphology differences and relative efficiencies of specific deposition mechanisms, on aerosol deposition patterns in the TB tree.
- Research Organization:
- Battelle Pacific Northwest Laboratories, Richland, WA
- OSTI ID:
- 6469232
- Journal Information:
- Bull. Math. Biol.; (United States), Journal Name: Bull. Math. Biol.; (United States) Vol. 45:3; ISSN BMTBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASYMMETRY
BIOLOGICAL EFFECTS
BODY
BRONCHI
CALCULATION METHODS
COMPARATIVE EVALUATIONS
DATA
DISTRIBUTION
EXPERIMENTAL DATA
GEOMETRY
INFORMATION
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
MATHEMATICAL MODELS
MATHEMATICS
MORPHOLOGY
NUMERICAL DATA
ORGANS
PARTICLES
PARTICULATES
PRIMATES
PROBABILITY
RESPIRATORY SYSTEM
SIMULATION
SYMMETRY
TISSUE DISTRIBUTION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASYMMETRY
BIOLOGICAL EFFECTS
BODY
BRONCHI
CALCULATION METHODS
COMPARATIVE EVALUATIONS
DATA
DISTRIBUTION
EXPERIMENTAL DATA
GEOMETRY
INFORMATION
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
MATHEMATICAL MODELS
MATHEMATICS
MORPHOLOGY
NUMERICAL DATA
ORGANS
PARTICLES
PARTICULATES
PRIMATES
PROBABILITY
RESPIRATORY SYSTEM
SIMULATION
SYMMETRY
TISSUE DISTRIBUTION
VERTEBRATES