Effect on ultraviolet mutagenesis of genes 32, 41, 44, and 45 alleles of phage T4 in the presence of wild-type or antimutator DNA polymerase
Journal Article
·
· Virology; (United States)
Temperature-sensitive alleles of four genes whose products are essential for DNA elongation in phage T4 were tested for their effects on uv mutagenesis in the presence of an antimutator polymerase allele, tsCB87, or the wild-type polymerase allele. The results suggest that the products of genes 32, 41, 44, and 45, in addition to the gene 43 polymerase, influence the accuracy of the DNA synthesis associated with uv mutagenesis. When considered in combination with previous observations, it appears that thymine dimers in phase T4 DNA may cause mutation through an error-prone repair process which employs a multienzyme system involving at least five components in a replication step, and a final ligation step.
- Research Organization:
- Univ. of Arizona, Tucson
- OSTI ID:
- 6839310
- Journal Information:
- Virology; (United States), Journal Name: Virology; (United States) Vol. 105:2; ISSN VIRLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENZYMES
ESCHERICHIA COLI
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
MICROORGANISMS
MUTAGENESIS
MUTANTS
NUCLEIC ACID REPLICATION
PARASITES
POLYMERASES
RADIATION EFFECTS
RADIATIONS
REVERTANTS
TEMPERATURE DEPENDENCE
ULTRAVIOLET RADIATION
VIRUSES
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BACTERIOPHAGES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENZYMES
ESCHERICHIA COLI
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
MICROORGANISMS
MUTAGENESIS
MUTANTS
NUCLEIC ACID REPLICATION
PARASITES
POLYMERASES
RADIATION EFFECTS
RADIATIONS
REVERTANTS
TEMPERATURE DEPENDENCE
ULTRAVIOLET RADIATION
VIRUSES