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Time dose relationships in endometrial adenocarcinoma: importance of the interval from external pelvic irradiation to surgery

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6839226
 [1]; ; ;
  1. Medical Coll. of Wisconsin, Milwaukee
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One hundred twenty-one patients with adenocarcinoma of the endometrium received external pelvic irradiation (EPI) as a preoperative surgical adjuvant to total abdominal hysterectomy between March, 1951 and February, 1977. Either 400 KVP x-rays, Cobalt teletherapy or 25 MeV photons were used. In more than one third of the hysterectomy specimens, there was no histopathological evidence of residual cancer. Statistical analysis shows a significant reduction in the proportion of positive specimens as the interval to hysterectomy increased. The data support the concept that adenocarcinomas are not radioresistant but may be slow to regress following irradiation. Caution is advised against making decisions about therapy based on histopathological findings in patients who receive surgery immediately following short course or intracavitary preoperative irradiation.
OSTI ID:
6839226
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:5
Country of Publication:
United States
Language:
English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
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ELECTROMAGNETIC RADIATION
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FEMALE GENITALS
HISTOLOGY
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
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ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
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ODD-ODD NUCLEI
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RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SURGERY
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YEARS LIVING RADIOISOTOPES