Stage I, grade III adenocarcinoma of the endometrium treated with surgery and irradiation. Sites of failure and correlation of failure rate with irradiation technique

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19840701)54:1<40::AID-CNCR2820540111>3.0.CO;2-T· OSTI ID:6800816

Bedwinek, J; Galakatos, A; Camel, M; Kao, M S; Stokes, S; Perez, C

Eighty-three patients treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH-BSO) and adjuvant irradiation for Stage I, grade III adenocarcinoma of the endometrium were reviewed. At 5 years, the overall survival was 71%, and the disease-free survival (excluding patients dying of intercurrent disease) was 79%. The failure rates for pelvis alone, pelvis plus distant, and distant alone were 4.8%, 4.8%, and 10.8%, respectively. The most common site of failure was the upper abdomen; 12% of all patients had a failure at this site, either alone or in conjunction with failure at another site. The 24% rate of failure in 50 patients receiving a preoperative implant and external irradiation was not significantly different from the 15% failure rate in 33 patients whose adjuvant irradiation consisted of a preoperative implant only. For the patients who had both an implant and external irradiation, the dose of external irradiation had no correlation with the rate of failure. In contrast, the number of milligram-hours delivered to the uterus by the preoperative implant had a strong inverse correlation with the rate of failure, both for patients receiving an implant only and for those receiving an implant plus external irradiation. The data suggest the following: (1) a high-intensity preoperative uterine implant may be an important adjunct to surgery; and (2) external pelvic irradiation in addition to the implant does not seem to be any more beneficial than an implant alone.

• Research Organization: Mallinckrodt Inst. of Radiology, St. Louis, MO
• OSTI ID: 6800816
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 54:1; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CARCINOMAS
DISEASES
DOSES
EVALUATION
EXTERNAL IRRADIATION
FEMALE GENITALS
IMPLANTS
INTERNAL IRRADIATION
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION DOSES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOLOGY
RADIOTHERAPY
SURGERY
SURVIVAL CURVES
THERAPY
UTERUS