Management of high-grade stage I adenocarcinoma of the endometrium: hysterectomy following low dose external beam pelvic irradiation

Journal Article · Fri Jan 31 23:00:00 EST 1986 · Gynecol. Oncol.; (United States)

DOI:https://doi.org/10.1016/0090-8258(86)90222-2· OSTI ID:5730880

Shimm, D S; Wang, C C; Fuller, Jr, A F; Nelson, Jr, J H; Nikrui, N; Young, R H; Scully, R E

Sixty-eight patients with FIGO stage I, grade 2 or 3 adenocarcinoma of the endometrium were treated according to a protocol involving 10 Gy external pelvic irradiation, prompt hysterectomy with surgical staging, and postoperative therapy individualized according to surgical-pathologic findings. Five-year survival for the entire group was 78%, 87% for those with grade 2 disease, and 59% for those with grade 3 disease. For patients whose disease was found to be confined to the uterus, surgical stage I, the 5-year survival was 98%. Patients with surgical stage I, grades 2 and 3 disease had 97 and 100% probabilities of surviving 5 years, respectively. Five-year disease-free probability was 96% for all patients with surgical stage I carcinoma, 97% for patients with grade 2 disease, and 94% for patients with grade 3 disease. Myometrial penetration influenced survival; no patient with less than 50% myometrial penetration died or suffered a relapse, while only 40% of patients with deeper penetration survived 5 years. Twenty-three percent of patients with surgically confirmed disease spread beyond the corpus survived 5 years; 29% remained disease-free at this interval. Ten of the 68 patients developed recurrences, none has had a known pelvic recurrence. Two major complications, one requiring surgery, were seen, both in patients receiving postoperative external beam irradiation. The rationale behind low-dose, preoperative external pelvic irradiation is described, and an approach to high-grade, FIGO stage I adenocarcinoma of the endometrium is outlined.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 5730880
• Journal Information: Gynecol. Oncol.; (United States), Journal Name: Gynecol. Oncol.; (United States) Vol. 2; ISSN GYNOA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BEAMS
BODY
CARCINOMAS
CONNECTIVE TISSUE
DISEASES
FEMALES
ION BEAMS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
PRIMATES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SURVIVAL TIME
THERAPY
TISSUES
VERTEBRATES
WOMEN